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为了探讨抗代谢药物对青光眼小梁切除术后包裹性囊状滤过泡形成的影响，本文分别对５０眼术中应用丝裂霉素Ｃ（ＭＭＣ）和４０眼术后结膜下注射５—氟尿嘧啶（５－Ｆｕ）的难治性青光眼进行分析。术后６个月，ＭＭＣ组手术成功率８６％；５－Ｆｕ组成功率８２．５％。包裹性囊状滤过泡的发生率，ＭＭＣ组１６％；５－Ｆｕ组１０％。结果表明，上述药物能明显减少滤过泡的瘢痕化，但不能减少包裹性囊状滤过泡的发生。男性、青少年性青光眼和以角膜缘为基底的结膜瓣发生率较高。
In order to investigate the effect of antimetabolites on the formation of enveloping cystic bleb after trabeculectomy in glaucoma, 50 cases were treated with mitomycin C (MMC) and 40 cases with subconjunctival injection of 5-fluorouracil (5-Fu) refractory glaucoma for analysis. At 6 months after operation, the success rate of operation was 86% in MMC group and 82.5% in 5-Fu group. The incidence of encapsulated cystic bleb was 16% in MMC group and 10% in 5-Fu group. The results show that the above drugs can significantly reduce the scarring of bleb, but can not reduce the occurrence of encapsulated bleb filtration bleb. Male, adolescent glaucoma and limbal-based conjunctival flap incidence higher.