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目的 探讨Ku抗体在我国结缔组织病 (CTD)中的分布及其临床意义。方法 制备兔胸腺丙酮粉 ,提取Ku抗原 ,以免疫双扩散法测定 5 0份正常人和 438份不同CTD患者血清中Ku抗体阳性率 ,分析Ku抗体阳性患者的临床和实验室特点。结果 438份CTD患者血清中 12例Ku抗体阳性 ,其中系统性硬化症多发性肌炎重叠结缔组织病 (SSc PM )占 9例。对SSc PM而言 ,Ku抗体的敏感性 6 0 0 % ,特异性 99 4%。Ku抗体阳性的SSc与阴性的SSc比较 ,发现阳性的SSc患者多同时有肌炎表现 ,两组间差异有极显著性 (P <0 0 1)。结论 Ku抗体并非常见 ,对SSc而言 ,Ku抗体与肌炎显著相关。Ku抗体阳性的SSc可能是SSc中的另一亚型 ,其临床特点还待更多病例观察随访。
Objective To investigate the distribution of Ku antibody in connective tissue disease (CTD) in China and its clinical significance. Methods The rabbit thymus acetone powder was prepared and Ku antigen was extracted. The positive rate of Ku antibody in the serum of 50 normal subjects and 438 patients with different CTD was determined by immunodiffusion method. The clinical and laboratory features of Ku antibody positive patients were analyzed. Results Sera from 438 CTD patients were positive for Ku antibody, of which systemic sclerosis polymyositis overlap connective tissue disease (SSc PM) accounted for 9 cases. For SSc PM, the Ku antibody has a sensitivity of 600% and a specificity of 99.4%. Ku antibody-positive SSc compared with negative SSc, found that positive patients with SSc more simultaneous myositis, the difference between the two groups was significant (P <0.01). Conclusions Ku antibody is not common, and for SSc, Ku antibody is significantly associated with myositis. Ku antibody-positive SSc may be another subtype in SSc, its clinical features have yet to be more cases of observation follow-up.