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作者将Kirsner按免疫复合物原理复制的家兔溃疡性结肠炎模型加以改进,即在Kirsner法的基础上添加一次1％福尔马林与25％冰醋酸2m1混合液灌肠进行模型复制。日本种大耳白兔♀♂兼用共44只,均健康无病,随机分为4组,对照组,柳氮磺吡啶组,低剂量5-氢基水杨酸甲酯盐酸盐(5-ASA-M低组)组和5-ASA-M高组。
The authors modified Kirsner’s model of ulcerative colitis in rabbits replicated on the principle of immune complexes by adding an enema of 1% formalin and 25% glacial acetic acid 2 ml on the basis of Kirsner’s method for model replication. A total of 44 Japanese white rabbits were used in this study. All were healthy and disease-free, and were randomly divided into 4 groups: control group, sulfasalazine group, low-dose methyl 5- ASA-M low group) and 5-ASA-M high group.