【摘 要】
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目的 探讨CDKN2BAS基因rs1333049位点及rs4977574位点多态性与川崎病及并发冠状动脉损伤(CAL)的关联性.方法 选取100例川崎病患儿作为研究组,100例健康婴幼儿作为对照组,提取外周血DNA并进行基因测序,分析CDKN2BAS基因的rs1333049位点及rs4977574位点的多态性.结果 研究组与对照组的CDKN2BAS基因rs1333049位点GG、CG、CC基因型分布和G、C等位基因频率比较,差异无统计学意义(P>0.05).研究组与对照组的CDKN2BAS基因rs4977
【机 构】
：
中南大学湘雅三医院儿科,湖南长沙 410013
论文部分内容阅读
目的 探讨CDKN2BAS基因rs1333049位点及rs4977574位点多态性与川崎病及并发冠状动脉损伤(CAL)的关联性.方法 选取100例川崎病患儿作为研究组,100例健康婴幼儿作为对照组,提取外周血DNA并进行基因测序,分析CDKN2BAS基因的rs1333049位点及rs4977574位点的多态性.结果 研究组与对照组的CDKN2BAS基因rs1333049位点GG、CG、CC基因型分布和G、C等位基因频率比较,差异无统计学意义(P>0.05).研究组与对照组的CDKN2BAS基因rs4977574位点AA、AG、GG基因型分布和G、A等位基因频率比较,差异均无统计学意义(P>0.05).川崎病合并CAL患儿与川崎病未合并CAL患儿CD-KN2BAS基因rs1333049位点及rs4977574位点的基因型分布和等位基因频率比较,差异均无统计学意义(P>0.05).结论 CDKN2BAS基因rs1333049位点及rs4977574位点多态性与川崎病发病及合并CAL均无明显关联性.
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