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本文就螺内酯具有抗雄激素的作用,设计了复方螺内酯擦剂用于临床治疗男型秃发及重症痤疮并对制剂的含量测定、稳定性以及正常人体透皮吸收进行了考察。认为复方螺内酯擦剂的质量控制可采用分光光度法在238±1nm及272±1nm波长处测定,按吸收度具有加和性的原则计算。正常皮肤对药物。的吸收随时间的延长而增加,6h后体内吸收药量最高。该制剂经加热消化含量及吸收峰均无改变。
In this paper, spironolactone has anti-androgen effect, designed compound spirolactone liniment for the treatment of male alopecia areata and severe acne, and the preparation of the content determination, stability and normal human transdermal absorption were investigated. The quality control of compound spirolactone liniment may be determined by spectrophotometry at wavelengths of 238 ± 1 nm and 272 ± 1 nm, calculated according to the principle of absorbability with additivity. Normal skin to drug. The absorption increased with time, and the highest dose absorbed in the body after 6h. The preparation has no change in the content of heat and digestion and the absorption peak.