自1947年海群生(枸橼酸乙胺嗪)用于临床以来,至今尚未被更理想的药物所取代,作为长期使用的药物,其是否有潜在致癌性的问题,目前已引起重视.近来国内外多用Ames试验检查化学物质的致突变性。鉴于Ames试验与动物诱癌试验的符合率较高,所以我们用鼠伤寒沙门氏菌微粒体系统检测海群生,以探索其是否有诱发癌症的可能. Since its use in the clinic in 1947, sea qun (diethylcarbamazine citrate) has not yet been replaced by more ideal drugs, as a long-term use of drugs, whether it has potential carcinogenicity, has drawn great attention recently. Ames test more than the use of chemicals to check the mutagenicity. In view of the high coincidence rate between the Ames test and the animal cancer-inducing test, we used the Salmonella typhimurium microsomal system to detect seaquats to explore whether it has the potential to induce cancer.