Deep vein thrombosis (DVT),which can lead to pulmonary embolism (PE),is a major contributor to the global disease burden and is the third most common cardiovascular pathology after coronary artery disease and stroke.Venous thromboembolic disease,which encompasses the disease entities of DVT and PE,affects up to 10 million cases every year and represents a serious and potentially life-threatening condition.Standard anticoagulation therapy alone is ineffective at promoting deep venous system thrombus removal.Many patients develop postthrombotic syndrome (PTS) despite being on adequate anticoagulation therapy.Aggressive therapy for rapid thrombus removal is important to prevent the development of PTS.Besides impeding the onset of PTS,rapid clearance of the thrombus is also required in the treatment of phleg masia cerulea dolens,an uncommon but life-threatening complication of acute DVT that can lead to arterial insufficiency,compartment syndrome,venous gangrene,and limb amputation.Manual aspiration thrombectomy (MAT) can provide rapid and effective therapy that could be compared to the open surgical thrombectomy approach with minimal risk of morbidity,mortality,or recurrence after surgery.Though many devices have been developed to date for pharmacomechanical thrombolysis,the cost of the treatment using these devices is very expensive.MAT is simple to perform,easy to lea,inexpensive,and rapid.This review will outline and dissect several studies and case reports,sourced from the PubMed database,on the subject of the use of MAT in treating inferior vena cava thrombosis and lower extremity DVT,including in patients with compression of the iliac vein and phlegmasia cerulea dolens.