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用免疫组织化学方法检测转化生长因子(TGF)β三型及其受体(TβR-Ⅰ)在细支气管肺泡细胞增生(BAH)和细支气管肺泡细胞癌(BAC)中的分布情况。结果示,大部分BAC和BAH病例均有一种以上TGF-β亚型和TβR-Ⅰ表达;BAC的TGF-β1和TGF-β3阳性率明显高于BAH;有二种以上TGF-β表达的BAC病例,其淋巴结转移发生率更高。提示增生和癌变的细支气管肺泡细胞均可合成和分泌TGF-β和TβR-Ⅰ,且TGF-β对BAC的发展起一定作用
Immunohistochemistry was used to detect the distribution of transforming growth factor (TGF) beta 3 and its receptor (TβR-I) in bronchioloalveolar cell proliferation (BAH) and bronchioloalveolar cell carcinoma (BAC). The results showed that most of the BAC and BAH cases had more than one TGF-β subtype and TβR-I expression; the positive rates of TGF-β1 and TGF-β3 in BAC were significantly higher than that in BAH; there were more than two types of BAC expressing TGF-β In cases, the incidence of lymph node metastasis is higher. The bronchioalveolar cells of both proliferative and carcinogenic cells can synthesize and secrete TGF-β and TβR-I, and TGF-β can play a role in the development of BAC.