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用免疫组织化学方法检测转化生长因子（ＴＧＦ）β三型及其受体（ＴβＲ－Ⅰ）在细支气管肺泡细胞增生（ＢＡＨ）和细支气管肺泡细胞癌（ＢＡＣ）中的分布情况。结果示，大部分ＢＡＣ和ＢＡＨ病例均有一种以上ＴＧＦ－β亚型和ＴβＲ－Ⅰ表达；ＢＡＣ的ＴＧＦ－β１和ＴＧＦ－β３阳性率明显高于ＢＡＨ；有二种以上ＴＧＦ－β表达的ＢＡＣ病例，其淋巴结转移发生率更高。提示增生和癌变的细支气管肺泡细胞均可合成和分泌ＴＧＦ－β和ＴβＲ－Ⅰ，且ＴＧＦ－β对ＢＡＣ的发展起一定作用
Immunohistochemistry was used to detect the distribution of transforming growth factor (TGF) beta 3 and its receptor (TβR-I) in bronchioloalveolar cell proliferation (BAH) and bronchioloalveolar cell carcinoma (BAC). The results showed that most of the BAC and BAH cases had more than one TGF-β subtype and TβR-I expression; the positive rates of TGF-β1 and TGF-β3 in BAC were significantly higher than that in BAH; there were more than two types of BAC expressing TGF-β In cases, the incidence of lymph node metastasis is higher. The bronchioalveolar cells of both proliferative and carcinogenic cells can synthesize and secrete TGF-β and TβR-I, and TGF-β can play a role in the development of BAC.