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肺癌是我国最常见的恶性肿瘤之一,其中85%为非小细胞肺癌,15%为小细胞肺癌。目前认为肺癌的形成是一个多因素、多步骤的过程,其具体的发病机制尚不清楚。microRNA(miRNA)是一类非编码的小分子RNA,能在转录后水平调控基因蛋白的表达,参与肿瘤细胞增殖、分化、侵袭和转移,对非小细胞肺癌的发生和发展与预后具有重要的影响。miR-125是当前研究miRNA在非小细胞肺癌发病机制的热点之一,本文就miR-125在肺癌中的研究进展作一综述。
Lung cancer is one of the most common malignant tumors in our country, of which 85% are non-small cell lung cancer and 15% are small cell lung cancer. At present, the formation of lung cancer is a multi-factor, multi-step process, the specific pathogenesis is not yet clear. MicroRNAs (miRNAs) are a class of non-coding small RNAs that regulate the expression of gene proteins at post-transcriptional level and are involved in the proliferation, differentiation, invasion and metastasis of tumor cells and are important for the development, progression and prognosis of non-small cell lung cancer influences. miR-125 is currently one of the hot spots in the study of miRNAs in the pathogenesis of non-small cell lung cancer. This article reviews the research progress of miR-125 in lung cancer.