大量的迹象表明细胞的原癌基因产物在正常和病态组织的细胞发育中起着调节作用。在细胞癌基因中ras基因和它们的产物研究得最好。高度保守的ras基因家族限制性地编码相应的P21蛋白,这种蛋白位于质膜的内表面,具有结合鸟苷酸和激活GTP酶的能力。认为ras蛋白是在信号转导通过质膜的过程中参与调节的。哺乳动物的ras基因家族成员在培养建 There are numerous indications that the cell’s proto-oncogene product plays a regulatory role in the development of normal and diseased tissue cells. The ras genes and their products are best studied in cell oncogenes. The highly conserved ras gene family restrictively encodes the corresponding P21 protein, which is located on the inner surface of the plasma membrane and has the ability to bind guanylic acid and activate GTPases. The ras protein is thought to be involved in the regulation of signal transduction through the plasma membrane. Mammalian ras gene family members are under construction