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柳胺苄心定(Labetalol、AH5158或Trandate,简称La)是70年代出现的第一个兼有β-和α-肾上腺能受体阻滞作用的药物。自1971年Boakes等首次报道以来,已在动物及人体进行了大量研究。该药独特的药理作用及其所致血流动力学变化引起人们注意,在现代治疗学的许多领域中发挥重要作用。
Labetalol (AH5158 or Trandate, La) was the first drug that appeared in the 1970s to block both β-and α-adrenergic receptors. Since the first report by Boakes et al. In 1971, a great deal of research has been conducted in animals and humans. The drug’s unique pharmacological effects and the consequent hemodynamic changes have drawn people’s attention and play an important role in many areas of modern therapeutics.