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目的了解镉的雄性生殖毒性机制。方法雄性ＳＤ大鼠皮下注射ＣｄＣｌ２（含镉０．５、１．０和２．０ｍｇ／ｋｇ）染毒，观察镉对性腺和附性腺的影响。结果中、高剂量染镉组的大鼠体重、附睾、前列腺、精囊和睾丸重量均显著低于对照组（Ｐ＜０．０１），且有明显的剂量－效应关系；中、高剂量组的睾丸、附睾、精囊和前列腺的脏器系数分别显著低于对照组和低剂量组（Ｐ＜０．０５）；低剂量组的精子含量和活率显著低于对照组、畸形率显著高于对照组（均Ｐ＜０．０１）；中剂量组的精子含量显著低于低剂量组、畸形率显著高于低剂量组（均Ｐ＜０．０１），且无活精子；高剂量组无精子。结论镉对性腺和附性腺具有明显的毒性。
Objective To understand the mechanism of male reproductive toxicity of cadmium. Methods Male Sprague-Dawley rats were subcutaneously injected with CdCl2 (0.5, 1.0 and 2.0 mg / kg cadmium) to observe the effect of cadmium on the gonads and gonadal glands. Results The body weight, epididymis, prostate, seminal vesicle and testis weight of rats in medium and high dose cadmium group were significantly lower than those in control group (P <0.01), and there was a significant dose-effect relationship. The organ coefficients of testis, epididymis, seminal vesicle and prostate were significantly lower than those of the control and low dose groups (P <0.05). The sperm content and viability of the low dose group were significantly lower than those of the control group (All P <0.01). The sperm content of the middle dose group was significantly lower than that of the low dose group, and the deformity rate was significantly higher than that of the low dose group (all P <0.01) . Conclusion Cadmium has obvious toxicity to gonad and gonadal gland.