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目的 对流行性脑脊髓膜炎病人脂肪代谢情况进行初步探讨。方法 用CX 5型全自动生化分析仪检测了 72例流行性脑脊髓膜炎病人总胆固醇、甘油三脂、血糖及肝功能 ,其中 36例完成极期与恢复期双份血检测 ;死亡的暴发型流脑 3例死后立即行肝穿刺电镜检查。结果 与恢复期相比 ,极期甘油三脂、总胆固醇明显下降 (P <0 0 5 ) ,而血糖明显升高 (P <0 0 1) ,此外AST、LDH在极期亦显著增高 (P <0 0 5 ) ;电镜显示肝脏脂肪浸润 ;36例病人中 ,有 15例在极期出现心功能不全。结论 流行性脑脊髓膜炎病人脂肪代谢异常 ,脂肪分解增加 ,肝脏脂肪浸润 ,心功能受到影响。血甘油三脂、总胆固醇可作为判定病人病情轻重和观察疗效的指标之一。
Objective To investigate the status of fat metabolism in patients with epidemic meningitis. Methods Total cholesterol, triglyceride, blood glucose and liver function were measured in 72 patients with epidemic meningitis by CX 5 automatic biochemical analyzer. 36 patients completed bipolar blood tests at both extreme and convalescent stages. Outbreaks of death Three cases of meningitis immediately after liver biopsy under electron microscopy. Results Compared with convalescent period, the triglyceride and total cholesterol in the extreme phase decreased significantly (P <0.05), while the blood glucose increased significantly (P <0.01). In addition, the levels of AST and LDH in the polar phase were also significantly increased (P <0 0 5); electron microscopy showed fatty infiltration of the liver; 36 patients, 15 cases of extreme cardiac failure occurs. Conclusions Patients with epidemic meningitis have abnormal fat metabolism, increased lipolysis, fatty infiltration of the liver, and impaired cardiac function. Blood triglycerides, total cholesterol can be used as judging the severity of patients and observe the efficacy of one of the indicators.