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目的探讨造影剂对肾功能影响,引起造影剂肾病(CIN)的易患因素及其防治。方法选择接受冠状动脉造影术患者222例,检测术前、术后24h、72h的血尿素氮、血肌酐(cr)。对造影后24～72h血肌酐较原来增高25%或者44μmol/L以上定义为CIN。结果肾功能不全组CIN发生率20%,明显高于术前肾功能正常组的4.7%,差异具有显著性(P<0.05)。非CIN患者,术中造影剂用量少,而术前补液量明显多于CIN患者,差异具有显著性(P<0.05)。结论造影剂可引起一过性肾功能改变,CIN与造影剂剂量、补液量密切有关。
Objective To investigate the effect of contrast medium on renal function, the predisposing factors of contrast-induced nephropathy (CIN) and its prevention and treatment. Methods A total of 222 patients undergoing coronary angiography were enrolled. Blood urea nitrogen and serum creatinine (Cr) were measured before and 24 h and 72 h after operation. 24 ~ 72h after angiography serum creatinine increased by 25% or 44μmol / L more than the original definition of CIN. Results The incidence of CIN in renal dysfunction group was 20%, which was significantly higher than that in normal renal function group (4.7%). The difference was significant (P <0.05). Non-CIN patients, intraoperative contrast agent less, and preoperative rehydration was significantly more than CIN patients, the difference was significant (P <0.05). Conclusion Contrast agent can cause transient renal function changes, CIN and contrast agent dose, fluid volume is closely related.