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目的 :研究贲门失弛缓症下段食管的应力 -生长关系。 方法 :将 2 0只猫随机分为对照组和贲门失弛缓症病变模型组 ,病变组于胃镜下在下食管括约肌 (L ES)处分 4点环行注射苄基二甲基十四烷氯化铵 (BAC) 0 .5 ml/点 ,对照组注射等量生理盐水。病变组于 4、6、8周后 ,对照组于 8周后 ,测 L ES压力 (L ESP)和食管体部收缩波幅。取食管下 1 / 3段测不同拉伸比下的压力 -容积 ,并以指数曲线拟合。将实验段食管垂直轴向剪成长度约 2 mm的环状 ,扫描读取管壁厚度、内外周径 ,再径向剪开食管环 ,扫描张开角 ,计算其残余应力。 结果 :病变组在注射 BAC后 4、6、8周 ,L ESP分别为 (31 .2± 5 .1 1 )、(30 .6± 3.6 1 )、(32 .2± 3.76 ) mm Hg(1 m m Hg=0 .1 33k Pa) ,较注射前显著增高 (P<0 .0 5、P<0 .0 1和 P<0 .0 1 ) ,而对照组较注射前无显著差异 (P>0 .0 5 ) ;两组动物食管体部收缩波幅均较注射前无显著变化。病变组 4、6周后下段食管的顺应性均较对照组显著降低 (P<0 .0 5 ) ,以注射后 4周最小。病变组下段食管内壁的残余应力较对照组均显著减小 (P<0 .0 5 ) ,但随病程的延长而逐渐接近对照组。 结论 :贲门失弛缓症食管下段的顺应性降低 ,并存在显著的异常力学特性
Objective: To study the stress-growth relationship of lower esophagus in achalasia. Methods: Twenty cats were randomly divided into control group and achalasia model group. The lesion group underwent endoscopic gastroscopic injection of benzyldimethyltetradecyl ammonium chloride BAC) 0 .5 ml / point, the control group was injected with the same amount of saline. After 4, 6 and 8 weeks in the lesion group, LES pressure and esophageal body contraction amplitude were measured in the control group after 8 weeks. The pressure-volume at different stretch ratios was taken 1/3 of the esophagus and fitted with an exponential curve. The experimental section of the esophagus vertical axis cut into a length of about 2 mm ring, scanning the wall thickness, internal and external diameter, and then radial cut open the esophageal ring, scanning open angle, calculate the residual stress. Results: L ESP at 4, 6 and 8 weeks after BAC injection were (31 .2 ± 5 .1 1), (30.6 ± 3.6 1), (32.2 ± 3.76) mm Hg mm Hg = 0.133kPa), which was significantly higher than that before injection (P <0.05, P <0.01 and P <0.01), while there was no significant difference in the control group before injection (P> 0 .0 5). There was no significant change in systolic amplitude of esophageal body between two groups before injection. Lesion group 4,6 weeks after the lower esophageal compliance were significantly lower than the control group (P <0. 05), the smallest 4 weeks after injection. Lesions lower esophageal wall residual stress than the control group were significantly reduced (P <0. 05), but with the course of the disease gradually approached the control group. Conclusions: The compliance of lower esophageal achalasia decreased, and there were significant abnormal mechanical properties