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目的:探讨经腹次全子宫切除术治疗子宫肌瘤的临床效果及对血清血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平的影响。方法:选择我院2014年2月~2016年2月收治的106例子宫肌瘤患者,参照抽签法分作对照组与研究组。对照组采用经腹全子宫切除术治疗,研究组采用经腹次全子宫切除术治疗。比较两组的手术时间,出血量,肛门排气时间,住院时间,手术前后VEGF、IL-6、IL-8、促卵泡生成素(FSH)、雌二醇(E2)、抗苗勒管激素(AMH)水平的变化及并发症的发生情况。结果:研究组的手术时间、出血量、肛门排气时间、住院时间均明显短于对照组(P<0.05)。手术前,两组血清VEGF、IL-6、IL-8、FSH、E2、AMH水平比较差异无统计学意义(P>0.05);手术后,研究组血清IL-6、IL-8、E2、AMH水平明显低于对照组(P<0.05),血清FSH水平明显高于对照组,差异具有统计学意义(P<0.05),两组血清VEGF水平比较差异无统计学意义(P>0.05)。研究组并发症的发生率显著低于对照组(P<0.05)。结论:采用经腹次全子宫切除术治疗子宫肌瘤患者可起到与经腹全子宫切除术相似的应用效果,但经腹次全子宫切除术对机体形成的创伤较小,利于术后卵巢功能的恢复,可能与其降低患者术后血清IL-6、IL-8、VEGF水平有关。
Objective: To investigate the clinical effects of transabdominal total hysterectomy on uterine fibroids and the effects on the levels of serum vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), interleukin-8 Impact. Methods: A total of 106 patients with uterine fibroids who were admitted from February 2014 to February 2016 in our hospital were divided into control group and study group according to the drawing method. The control group was treated with transabdominal hysterectomy, and the study group was treated with abdominal subtotal hysterectomy. The operation time, bleeding volume, anal exhaust time, hospitalization time, VEGF, IL-6, IL-8, follicle stimulating hormone (FSH), estradiol (E2), anti-Mullerian hormone (AMH) levels and the incidence of complications. Results: The operation time, bleeding volume, anal exhaust time and hospital stay in study group were significantly shorter than those in control group (P <0.05). There was no significant difference in serum VEGF, IL-6, IL-8, FSH, E2 and AMH between the two groups before surgery (P> 0.05) The level of serum AMH was significantly lower than that of the control group (P <0.05). The level of serum FSH was significantly higher than that of the control group (P <0.05). There was no significant difference in serum VEGF between the two groups (P> 0.05). The incidence of complications in study group was significantly lower than that in control group (P <0.05). Conclusion: The treatment of uterine fibroids by abdominal subtotal hysterectomy can be used with transabdominal hysterectomy similar effect, but the abdominal subtotal hysterectomy trauma to the formation of smaller body, which will benefit the postoperative ovary Function recovery may be related to reducing postoperative serum levels of IL-6, IL-8 and VEGF.