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目的:探讨同种异体肾移植术后患者血清细胞因子(IL-2、IL-6、IL-8、IL-10)表达与亚临床排斥反应的关系。方法:采用ELISA检测15例亚临床排斥反应患者(亚临床排斥反应组)血清细胞因子,并与23例无排斥反应患者(无排斥反应组)和20例健康体检者(正常对照组)进行比较。结果:肾移植患者术后4个月肾移植患者血清IL-2、IL-6、IL-8、IL-10水平高于正常对照组,其中IL-6、IL-8、IL-10与正常对照组和无排斥组相比有统计学差异(P<0.05);亚临床排斥反应组干预后血清细胞因子水平明显降低,均达到正常值,其中IL-6、IL-8、IL-10与干预前比较有统计学差异(P<0.05)。结论:术后IL-10与IL-6、IL-8的动态检测,对于及早发现亚临床排斥反应和干预疗效的评估具有重要意义。
Objective: To investigate the relationship between the expression of serum cytokines (IL-2, IL-6, IL-8 and IL-10) and subclinical rejection in allogeneic kidney transplantation patients. Methods: Serum cytokines levels in 15 patients with subclinical rejection (subclinical rejection) were measured by ELISA and compared with 23 patients without rejection (no rejection group) and 20 healthy subjects (normal control group) . Results: The levels of IL-2, IL-6, IL-8 and IL-10 in renal transplant recipients at 4 months after operation were significantly higher than those in normal controls. IL-6, IL-8 and IL- IL-6, IL-8, IL-10 and IL-6 were significantly lower in the control group than in the non-rejection group (P <0.05). The levels of serum cytokines in the subclinical rejection group were significantly lower Before intervention there was a statistically significant difference (P <0.05). Conclusion: The dynamic detection of postoperative IL-10, IL-6 and IL-8 is of great significance for the early detection of subclinical rejection and intervention efficacy.