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[目的]探讨乳腺癌患者外周血中调节性T细胞(regulatory T cells,Tregs)数量的变化及意义。[方法]选取35例未经治疗的乳腺癌患者、35例术后并化疗后的乳腺癌患者和25例健康人,采集其外周抗凝血,用流式细胞术检测CD4+CD25+CD127-调节性T细胞的表达。[结果]未经治疗的乳腺癌患者外周血中CD4+CD25+CD127-的表达显著高于健康人,差异有统计学意义;术后并化疗后的乳腺癌患者外周血中CD4+CD25+CD127-的表达与正常人无明显差异。[结论]乳腺癌患者外周血中CD4+CD25+CD127-调节性T细胞的比例增加可能引起乳腺癌免疫逃逸,并可能在乳腺癌的发生发展中起重要作用。
[Objective] To investigate the changes and significance of the number of regulatory T cells (Tregs) in peripheral blood of breast cancer patients. [Method] 35 cases of untreated breast cancer, 35 cases of postoperative and post-chemotherapy breast cancer and 25 healthy individuals were collected to collect anticoagulated blood. Flow cytometry was used to detect the expression of CD4 + CD25 + CD127- Regulatory T cell expression. [Results] The expression of CD4 + CD25 + CD127- in peripheral blood of untreated breast cancer patients was significantly higher than that of healthy people, the difference was statistically significant. The levels of CD4 + CD25 + CD127 - The expression of no significant difference with normal people. [Conclusion] The increase of the proportion of CD4 + CD25 + CD127-regulatory T cells in peripheral blood of breast cancer patients may cause immune escape in breast cancer and may play an important role in the occurrence and development of breast cancer.