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目的:探讨糖尿病低血糖与严重心血管事件发病率的相关性。方法:对接受降血糖治疗期间因低血糖诱发严重心血管事件的668例门诊及住院的糖尿病患者的临床资料进行回顾性分析。结果:668例糖尿病患者共发生严重心血管事件109例,发生率为16.3%。低血糖组各项严重心血管事件发生率均高于非低血糖组,差异有统计学意义(P<0.05)。年龄增长、既往患心血管疾病、血糖达标时间、低血糖持续时间、合并严重肝肾功能异常诱发严重心血管事件的OR值分别为1.680、5.557、0.660、1.984、3.059。结论:患者年龄增长、既往患心血管疾病、低血糖持续时间长、合并严重肝肾功能异常均为低血糖诱发严重心血管事件的独立危险因素,血糖达标时间长为独立保护性因素。
Objective: To investigate the relationship between the incidence of diabetes mellitus and severe cardiovascular events. Methods: The clinical data of 668 outpatients and inpatients with diabetes who underwent hypoglycemia-induced severe cardiovascular events during the hypoglycemic treatment were analyzed retrospectively. Results: There were 109 cases of serious cardiovascular events in 668 diabetic patients, the incidence was 16.3%. The incidence of serious cardiovascular events in the hypoglycemia group was significantly higher than that in the non-hypoglycemia group (P <0.05). The OR values of age, previous history of cardiovascular disease, time to blood glucose compliance, duration of hypoglycemia, and severe cardiovascular events associated with severe hepatic and renal dysfunction were 1.680, 5.557, 0.660, 1.984 and 3.059, respectively. CONCLUSION: Patients with age-related and previous cardiovascular diseases, long duration of hypoglycemia, and severe liver and kidney dysfunction are independent risk factors for severe cardiovascular events induced by hypoglycemia. The long duration of glycemic control is an independent protective factor.