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通过手性硝基烯胺(4)与α-甲基-δ-戊内酯烯醇锌盐发生加成消除反应解决了倍半萜Capnellene类合成中构筑不对称季碳这个难题,对映体过量(e. e. )为94％。由L-脯氨酸经14步实现了(一)-△~(9(12))-Capnellene类的合成中间体——光学活性5-甲基-8-羟基双环[3 3,0]-2-辛酮(13)的对映选择合成。
Addition-elimination reaction of chiral nitro-enamine (4) with zinc salt of α-methyl-δ-valerolactone solved the problem of asymmetric quaternary carbon in the synthesis of sesquiterpenoids. Enantiomer The excess (ee) is 94%. The synthesis intermediate of optically active 5-methyl-8-hydroxybicyclo [3 3,0] - (9) - Enantioselective synthesis of 2-octanone (13).