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目的探讨碱性成纤维细胞生长因子I型受体(FGFR1)在尖锐湿疣(CA)中的表达及其临床意义。方法应用免疫组化SP法分别检测FGFR1在33例尖锐湿疣和10例正常人皮肤组织中的表达情况。结果正常对照包皮组织中FGFR1无或仅有弱的表达,CA皮损组织则呈强阳性表达,两组间比较有极显著统计学意义(P<0.001)。结论 FGFR1在尖锐湿疣组织中过度表达,提示其可能在促真皮毛细血管生成和表皮细胞增殖中发挥重要作用。
Objective To investigate the expression of basic fibroblast growth factor type I receptor (FGFR1) in condyloma acuminatum (CA) and its clinical significance. Methods Immunohistochemical SP method was used to detect the expression of FGFR1 in 33 cases of condyloma acuminata and 10 cases of normal human skin. Results There was no or only weak expression of FGFR1 in normal control foreskin tissues and strong positive expression in CA lesions. There was significant difference between the two groups (P <0.001). Conclusion FGFR1 overexpression in condyloma acuminatum suggests that it may play an important role in epidermal cell proliferation and epidermal cell proliferation.