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细胞内多种蛋白质前体比如细胞基质金属蛋白酶、生长因子、激素、受体等在成熟之前,必须经过Furin等蛋白转化酶对其进行剪切,才能发挥生物学功能.这些蛋白质中部分成员与肿瘤的发生、发展密切相关,因此Furin等蛋白转换酶活性及其对底物剪切的调控已成为肿瘤防治领域的研究靶点.研究表明Notch-1信号在胰腺癌细胞中处于高活化状态,与胰腺癌的发生及进展息息相关,阻断Notch-1激活可抑制胰腺癌细胞的生长.虽然,Furin对Notch-1的剪切是Notch-1活化的关键步骤,有关这一生物过程的调节,目前不甚清楚.几乎所有的实体瘤均存在非受体酪氨酸激酶c-Src的过度激活,它主要通过磷酸化修饰作用调节下游信号进而影响肿瘤细胞的生物学行为.猜测c-Src可能对Notch-1活化有重要的影响作用.从Notch-1信号通路、c-Src、高尔基体内Furin与Notch-1的相互作用等方面来阐述它们之间的关系.
A variety of intracellular protein precursors such as cell matrix metalloproteinases, growth factors, hormones, receptors, etc., before maturation, must Furin and other protein invertase to cut it in order to play a biological function of these proteins and some members of Therefore, the activity of protein-converting enzyme such as Furin and its regulation of substrate cleavage have become the research targets in the field of tumor prevention and treatment.Research shows that Notch-1 signal is highly activated in pancreatic cancer cells, It is closely related to the occurrence and progression of pancreatic cancer, blocking the activation of Notch-1 can inhibit the growth of pancreatic cancer cells.Although Furin’s Notch-1 cleavage is a key step of Notch-1 activation, the regulation of this biological process, At present, it is not clear that almost all solid tumors exist over-activation of non-receptor tyrosine kinase c-Src, which mainly regulates the downstream signals through phosphorylation and thus affects the biological behavior of tumor cells.It is speculated that c-Src may On Notch-1 activation has a significant impact on the role of the Notch-1 signaling pathway, c-Src, Golgi in vivo Furin and Notch-1 interaction and so on between them Department.