论文部分内容阅读
所有细胞都会发生凋亡,因此很难发现仅与癌细胞有关而不影响正常细胞的可供利用的靶标。研究人员最近发现一个小分子,它能在各型癌细胞系和小鼠模型中诱导细胞凋亡,且对正常细胞无相关毒性。现行开发的许多治疗方法基于触发细胞凋亡过程中的早期和中间步骤,因此在其下游发生突
Apoptosis occurs in all cells, making it difficult to find available targets that are only related to cancer cells and do not affect normal cells. Researchers have recently discovered a small molecule that induces apoptosis in all types of cancer cell lines and mouse models with no toxicities to normal cells. Many treatments currently under development are based on the early and intermediate steps in triggering apoptosis and therefore occur downstream