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催醒宁化学名为1,3,3-三甲基-5-二甲胺基甲酰氧基吲哚满盐酸盐,结构式: 1964年,中国人民解放军59176部队根据依色林(Eserine,毒扁豆硷)的结构,设计合成了本品。1965年,Ahmed和Robinson报道了这一化合物的合成方法,但迄今尚未见到有关药理、生化等方面的实验报告。经我们研究证明,催醒宁为可逆性胆碱酯酶抑制药。对酶的抑制作用比依色林强;具有同依色林相似的中枢作用,但毒性较低,作用时间较长。1974年济南部
Reminding Ning chemical name is 1,3,3-trimethyl-5-dimethylcarbamoyloxy indoline hydrochloride, structural formula: In 1964, the Chinese People’s Liberation Army 59176 units according to the ezine (Eserine, Poisonous glycosides) structure, the design and synthesis of the product. In 1965, Ahmed and Robinson reported the synthesis of this compound, but so far no experimental reports on pharmacology, biochemistry and other aspects have been found. Proved by our research, reminder Ning reversible cholinesterase inhibitors. Inhibition of the enzyme than the strong forest color; with similar forest color similar to the central role, but less toxic, longer duration of action. Jinan in 1974