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近年来研究发现肺气肿发生过程中常伴有异常的纤维组织增生 ,早期以Ⅲ型胶原增加为主[1] 。我们通过蛋白激酶Ｃ(ＰＫＣ) 抑制因子κＢ(ｉκＢ)信号传导途径的研究来探讨其对木瓜蛋白酶致大鼠肺气肿小气道平滑肌细胞及肺组织α1(Ⅰ )、α1(Ⅲ )前胶原 [α1(Ⅰ )、α1(Ⅲ )ＰＣ]
In recent years, studies found that emphysema often accompanied by abnormal fibrous tissue hyperplasia, increased early to type Ⅲ collagen [1]. We investigated the effect of PKC inhibitor kappaB (iκB) signaling pathway on the expression of α1 (Ⅰ), α1 (Ⅲ) procollagen in small airway smooth muscle cells and pulmonary tissue of rats with emphysema induced by papain [ α1 (Ⅰ), α1 (Ⅲ) PC]