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目的研究妊娠期高血压疾病患者子宫蜕膜组织中Th1和Th2细胞比率变化,探讨其变化在发病中的作用。方法河北医科大学第二临床医学院于2004年2～9月采集12例正常妊娠孕妇,10例妊娠期高血压和25例子疒间前期患者子宫蜕膜组织,采用流式细胞技术分别检测Th1/Th2细胞比率。结果(1)子疒间前期组和妊娠期高血压组Th1/Th2细胞比率明显高于正常妊娠组(P<0.05)。(2)子疒间前期组Th1/Th2比率明显高于其他两组(P<0.01),妊娠期高血压组明显高于正常妊娠组(P<0.05)。在子疒间前期组,随病情的严重程度的增加,其比率变化呈加重趋势,但与孕周无明显关系。(3)子疒间前期患者Th1/Th2比率与平均动脉压、24h尿蛋白量呈正相关(P均<0.01)。结论Th1/Th2比率变化可能是妊娠期高血压疾病发病的重要原因。
Objective To study the changes of Th1 and Th2 cell ratio in uterine decidua in patients with gestational hypertension and to explore the role of the changes in pathogenesis. Methods The uterine decidua tissue of 12 normal pregnant women, 10 gestational hypertension patients and 25 preeclampsia patients were collected from February to September 2004 in the Second Clinical Medical College of Hebei Medical University. Flow cytometry was used to detect the expression of Th1 / Th2 cell ratio. Results (1) The ratio of Th1 / Th2 cells in preeclampsia group and gestational hypertension group was significantly higher than that in normal pregnancy group (P <0.05). (2) The ratio of Th1 / Th2 in the premenstrual group was significantly higher than that in the other two groups (P <0.01). The gestational hypertension group was significantly higher than that in the normal pregnancy group (P <0.05). In the prenatal period between the pre-group, with the severity of the disease increased, the rate showed an increasing trend, but no significant relationship with gestational age. (3) There was a positive correlation between Th1 / Th2 ratio and mean arterial pressure and urinary protein in 24h (P <0.01). Conclusion The change of Th1 / Th2 ratio may be the important reason of the incidence of hypertensive disorders during pregnancy.