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目的:探讨2型糖尿病患者血清同型半胱氨酸(Hcy)水平与型糖尿病各类并发症的关系。方法:在198例经二甲双胍控制血糖的患者中,治疗组96例同时服用叶酸和维生素B6控制Hcy,5 a后比较Hcy和糖尿病各类并发症的发病率。结果:治疗组中糖尿病合并脑部病变、合并冠心病、合并肾病病变与对照组有显著性差异且随着并发症的加重差异增大。结论:空腹血清tHcy水平是糖尿病并发症的的一个重要因素,降低糖尿病患者的血清tHcy水平对降低糖尿病的肾病、心脏病、脑部等并发症具有重要的临床意义。
Objective: To investigate the relationship between serum homocysteine (Hcy) and various complications of type 2 diabetes in type 2 diabetic patients. Methods: Among 198 patients with glycemia controlled by metformin, 96 patients in the treatment group took folic acid and vitamin B6 simultaneously to control Hcy. After 5 years, the incidence of Hcy and various complications of diabetes were compared. Results: In the treatment group, there was a significant difference between the diabetic group complicated with brain lesion, coronary heart disease and nephropathy with the control group, and the difference increased with the increase of complications. Conclusion: Fasting serum tHcy level is an important factor in the complication of diabetes. Reducing serum tHcy level in diabetic patients has important clinical significance in reducing the complications of diabetic nephropathy, heart disease and brain.