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目的 观察缺血预处理 (ischemicpreconditioning ,IPC)对缺血再灌注的大鼠肝脏的保护作用。 方法 建立大鼠肝脏缺血再灌注 (ischemiareperfusion ,I/R)损伤模型 ,选取肝脏损伤时的典型指标 :血清丙氨酸转氨酶 (ALT)、天冬氨酸转氨酶(AST)、乳酸脱氢酶 (LDH) ,肝组织中丙二醛 (MDA)、过氧化物歧化酶 (SOD)、组织中中性粒细胞 (PMNs)浸润量等 ,比较缺血预处理组与I/R组以及各预处理组间各种指标的含量变化情况 ,用统计学方法处理结果。结果 预处理组中ALT、AST、LDH、MDA、SOD、PMNs等指标较I/R组有明显变化。结论 各预处理组生化酶的含量和脂质过氧化物的含量减少 ,抗氧自由基能力增强 ,组织中PMNs浸润量降低提示缺血预处理对肝脏I/R损伤有显著的保护作用。尤其是一次缺血 10min再灌注 10min的预处理保护效果最佳。
Objective To observe the protective effect of ischemic preconditioning (IPC) on rat liver after ischemia-reperfusion. Methods The model of liver ischemia / reperfusion (I / R) injury in rats was established. The typical indexes of hepatic injury were selected as follows: serum ALT, AST and LDH LDH), malondialdehyde (MDA), superoxide dismutase (SOD) and PMNs infiltration in the liver tissue were compared between the ischemic preconditioning group and the I / R group and the pretreatment Changes in the content of various indicators between groups, using statistical methods to deal with the results. Results The pretreatment group ALT, AST, LDH, MDA, SOD, PMNs and other indicators than the I / R group had significant changes. Conclusion The contents of biochemical enzymes and lipid peroxides in each pretreatment group were decreased, and the ability of antioxidant free radicals was enhanced. The decrease of PMNs infiltration in the pretreatment group suggested that ischemic preconditioning had a significant protective effect on liver I / R injury. In particular, an ischemic 10min reperfusion 10min pretreatment protection best.