T细胞是机体的主要免疫细胞,且在适应性免疫中起到主要作用。而T细胞受体(TCR)是T细胞表面特异性受体,是识别抗原的主要部位;TCR具有多样性和特异性,其中,最具多样性的是T细胞受体β链可变区(TCR Vβ),TCR Vβ的研究可为临床疾病的诊断和治疗提供新的思路和方向。TCR Vβ家族在各种疾病的动物模型的研究中具有重要的意义和应用价值,本文将对Vβ亚家族偏向取用在小鼠模型中的研究进展进行综述。 T cells are the body’s major immune cells and play a major role in adaptive immunity. The T cell receptor (TCR) is a T cell surface-specific receptor that is recognized as the main part of the antigen; TCR diversity and specificity, of which the most diverse is the T cell receptor β chain variable region TCR Vβ), TCR Vβ can provide new ideas and directions for the diagnosis and treatment of clinical diseases. The TCR Vβ family has important significance and application value in the study of animal models of various diseases. This article reviews the research progress of the bias of Vβ subfamily in the mouse model.