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目的探讨L-卡尼汀对心肌顿抑的保护作用及机制。方法采用实验性家兔心肌顿抑模型,18只家兔随机分成假手术组(SH组)、缺血/顿抑组(IS组)和L-卡尼汀处理组(LCS组)。开胸结扎兔左冠状动脉前降支20min,然后松扎6h。观察心肌组织中SOD活性和MDA的含量及心肌组织中ATP的含量。结果LCS组心肌组织中SOD活性升高(P<0.01),MDA的含量降低(P<0.01),心肌组织中ATP的含量明显升高(P<0.01)。结论L-卡尼汀可以改善心肌能量代谢,清除氧自由基,对心肌顿抑有良好的保护作用。
Objective To investigate the protective effect of L-carnitine on myocardial stunning and its mechanism. Methods Rabbit model of myocardial stunning was established. Eighteen rabbits were randomly divided into SH group, IS group and L-carnitine group (LCS group). Thoracotomy rabbit left anterior descending coronary artery 20min, and then loose tie 6h. The activity of SOD and content of MDA and the content of ATP in myocardium were observed. Results The activity of SOD in myocardial tissue of LCS group was increased (P <0.01), the content of MDA was decreased (P <0.01), the content of ATP in myocardium was increased significantly (P <0.01). Conclusion L-carnitine can improve myocardial energy metabolism, scavenging oxygen free radicals, myocardial stunning has a good protective effect.