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目的探讨腹腔镜下与开腹楔形切除胃部胃肠道间质瘤(GIST)的疗效与安全性。方法选取自2012年5月至2014年10月在盘锦市中心医院手术治疗的100例GIST患者为研究对象,按照完全随机法将患者分为腹腔镜组和开腹组,每组50例。观察两组患者的手术时间、术中出血量、术后排气时间、术后住院时间、术后进食流质饮食时间、并发症发生情况。比较两组患者术后12个月的Karnofsky功能状态评分(KPS)差异。结果两组患者在手术时间、术中出血量、术后排气时间、术后住院时间、术后进食流质饮食时间方面相比,差异均有统计学意义(均P<0.05)。腹腔镜组患者的随访时间为(14±11)个月,开腹组随访时间为(15±9)个月,两组患者的术后1年KPS评分相比,差异无统计学意义(P<0.05)。两组患者并发症比较差异有统计学意义(P<0.05)。结论腹腔镜下楔形切除胃部GIST安全性高,患者并发症发生率低,值得临床推广使用。
Objective To investigate the efficacy and safety of laparoscopic and open wedge resection of gastrointestinal stromal tumors (GIST). Methods From May 2012 to October 2014, 100 GIST patients who underwent surgical treatment in Central Hospital of Panjin were selected as study subjects. Patients were divided into laparoscopic group and laparotomy group according to a completely randomized method, 50 cases in each group. Two groups of patients were observed operation time, blood loss, postoperative exhaust time, postoperative hospital stay, postoperative eating liquid diet time, complications. The Karnofsky functional status scores (KPS) differences between the two groups at 12 months were compared. Results There were significant differences between the two groups in terms of operation time, blood loss, postoperative exhaust time, postoperative hospital stay and postoperative dietary fluid intake time (all P <0.05). The follow-up time was (14 ± 11) months in laparoscopic group and (15 ± 9) months in laparotomy group. There was no significant difference in KPS score between the two groups at 1 year after operation (P <0.05). There was significant difference between the two groups in complication (P <0.05). Conclusion Laparoscopic wedge resection of stomach GIST high safety, low incidence of complications, it is worth promoting the use of the clinic.