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目的检测原发性肝癌患者血清血管内皮细胞生长因子和甲胎蛋白的含量并分析其相关性。方法用ELISAFA法检测35例健康对照和228例PHC患者血清VEGF和AFP含量,分析VEGF、AFP及其联合检测对PHC的诊断价值和临床分期及预后的关系。结果 VEGF水平(pg/ml)PHC组(398.4±153.1)和健康对照组(166.8±84.2)比较差异有统计学意义(P<0.01),VEGF和AFP对PHC诊断的敏感性和特异性分别为(71.23%/73.29%)和(80.64%/83.87%),VEGF和AFP之间无相关性,二者联合检测可提高对PHC诊断的敏感性(91.81%)和准确度(92.22%)。结论血清VEGF与AFP联合测定可作为诊断PHC的重要指标。
Objective To detect the levels of serum vascular endothelial growth factor and alpha-fetoprotein in patients with primary liver cancer and analyze their correlation. Methods Serum levels of VEGF and AFP in 35 healthy controls and 228 PHC patients were detected by ELISA. The relationship between VEGF, AFP and their combined diagnosis of PHC and clinical stage and prognosis was analyzed. Results The VEGF level (pg / ml) in PHC group (398.4 ± 153.1) and healthy control group (166.8 ± 84.2) was significantly different (P <0.01). The sensitivity and specificity of VEGF and AFP in diagnosing PHC were (71.23% / 73.29%) and (80.64% / 83.87%) respectively. No correlation was found between VEGF and AFP. The combination of the two methods could increase the sensitivity (91.81%) and accuracy (92.22%) of the diagnosis of PHC. Conclusion The combination of serum VEGF and AFP can be used as an important index in the diagnosis of PHC.