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目的 总结经内镜全层切除(EFR)胃黏膜下肿瘤的疗效和安全性.方法 经胃镜及超声胃镜检查明确诊断胃黏膜下肿瘤患者96例,年龄60岁以上,均实施EFR.结果 96例患者瘤体均完整切除.1例患者因术中出血,内镜下难以控制而转外科手术,术后恢复良好.20例患者穿孔伤口行内镜下荷包缝合术,其余均以钛夹缝合.手术时间(63.4±39.1)min,使用钛夹(9.0±5.7)枚.瘤体部位:胃底及底体交界78例,胃体10例,胃窦2例,贲门5例,胃角1例.病理结果:梭形细胞瘤93例,平滑肌瘤2例,神经鞘瘤1例.术后病理均显示切缘阴性.随访1~8年,均未见肿瘤复发和转移.结论 对60岁以上患者,EFR胃黏膜下肿瘤安全、有效.“,”Objective To summarize the efficacy and safety of endoscopic full-thickness resection(EFR) in the treatment of gastric submucosal tumor .Methods The EFR was performed in 96 patients aged more than 60 years old with gastric submucosal tumor ,which was diagnosed definitely by gastric endoscopy and ultrasound gastric endoscopy .Results The gastric submucosal tumor was completely resected in all 96 cases ,of whom one case received open surgery because of uncontrollable bleeding and recovered well .Of 96 cases ,the wound perforation occurred in 20 cases , which were treated with purse string suture and the wound in the others were closed by titanium cliper .The operation lasted for (63.4 ± 39.1) minutes and (9.0 ± 5.7) titanium clipers were used in average .The lesions located in the fundus of the stomach in 78 cases ,in the body of stomach in 10 cases ,in the antrum in 2 cases ,in the cardia in 5 cases ,and stomach angle in 1 case .The pathological diagnoses were spindle cell tumor in 93 cases ,leiomyoma in 2 cases ,and nerve sheath tumor in 1 case . Pathological examination of the edge of incision showed negative .There were no local relapse and metastasis during 1 to 8 years of follow up .Conclusion The EFR is effective and safe in the treatment of gastric submucosal tumors in the patients aged more than 60 years old .