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目的了解烧伤创面葡萄球菌属分离株的耐药特性。方法用K-B法测定14种常用抗菌药物的敏感性;头孢西丁纸片法测定MRSA和MRCNS;D试验测定克林霉素的诱导耐药表型。结果2005年1月-2007年12月从烧伤患者创面共检出葡萄球菌属378株,检出率最高的是表皮葡萄球菌(43.1%),金黄色葡萄球菌(41.6%)和溶血葡萄球菌(11.1%),其他葡萄球菌少见;3种主要葡萄球菌对万古霉素全部敏感,对替考拉宁、米诺环素、呋喃妥因和利福平耐药率较低(3.7%～19.0%)外,其他抗菌药物的耐药率在54.1%～100.0%;MRSA检出率为81.5%,MRCNS检出率分别为55.6%和66.7%,在红霉素耐药,而克林霉素敏感的葡萄球菌属中,D试验总阳性率48.2%,分别为金黄色葡萄球菌49.1%,表皮葡萄球菌44.2%,溶血葡萄球菌57.1%。结论葡萄球菌属是引起烧伤创面感染最重要的病原菌之一,且耐药率日趋严重,MRSA、MRCNS和克林霉素诱导耐药率高,已对创面感染治疗构成极大的困难,必须引起临床的高度重视。
Objective To understand the drug resistance of Staphylococcus isolates from burn wounds. Methods K-B method was used to determine the sensitivity of 14 commonly used antimicrobial agents. Cefoxitin disk method was used to determine MRSA and MRCNS. D test was used to determine the induced drug resistance phenotype of clindamycin. Results A total of 378 staphylococci were isolated from wounds of burn patients from January 2005 to December 2007. The highest detection rates were Staphylococcus epidermidis (43.1%), Staphylococcus aureus (41.6%) and Staphylococcus haemolyticus 11.1%). Other Staphylococcus aureus were rare. The three major staphylococci were all sensitive to vancomycin. The rates of resistance to teicoplanin, minocycline, nitrofurantoin and rifampin were low (3.7% -19.0%) , And the rates of other antibiotics were between 54.1% and 100.0%. The detection rate of MRSA was 81.5% and the detection rates of MRCNS were 55.6% and 66.7%, respectively. In erythromycin-resistant and clindamycin-sensitive grape In Coccus, the total positive rate of D test was 48.2%, which was 49.1% of Staphylococcus aureus, 44.2% of Staphylococcus epidermidis and 57.1% of Staphylococcus haemolyticus respectively. Conclusions Staphylococcus is one of the most important pathogens that cause wound infection in wounds, and the drug resistance rate is getting more and more serious. MRSA, MRCNS and clindamycin induce high resistance rates, which have caused great difficulties in the treatment of wound infections and must be caused Clinical attention.