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目的探讨分析原发性肝癌的临床特点,为早期诊断提供参考。方法选择2010年12月~2012年12月本院收治的90例原发性肝癌患者作为本次研究对象,回顾性分析上述病例的临床资料,选取同期体检的90例健康志愿者做对照,分析原发性肝癌的临床特点。结果 90例患者的临床表现缺乏特异性,包括肝区疼痛、乏力、消瘦、食欲下降、肝肿大等,男性患病率81.11%,女性患病率18.89%,40~68岁发病64例,占71.11%,肝硬化导致肝癌的比例为71.11%,乙肝病毒感染率为91.11%,HBsAg阳性、抗-HBe阳性和抗-HBc阳性是主要感染模式,占55.56%,原发性肝癌血清甲胎球蛋白(AFP)和α-L-岩藻糖苷酶(AFU)分别为(511.8±57.2)ng/ml和(39.9±20.3)U/L,两项指标均显著高于健康志愿者(P<0.05)。结论中老年男性患者是原发性肝癌的高危人群,乙型肝炎和肝硬化是诱发肝癌的重要病因,AFP和AFU是其重要的临床检查指标,上述特点对早期诊断具有重要的临床价值。
Objective To analyze the clinical features of primary liver cancer and provide a reference for early diagnosis. Methods 90 patients with primary liver cancer treated in our hospital from December 2010 to December 2012 were enrolled in this study. The clinical data of the above cases were retrospectively analyzed. 90 healthy volunteers in the same period were selected for comparison. Primary liver cancer clinical features. Results The clinical manifestations of 90 patients lacked specificity, including liver pain, fatigue, weight loss, loss of appetite, hepatomegaly, male prevalence rate of 81.11%, female prevalence rate 18.89%, 40 to 68-year-old incidence of 64 cases, Accounting for 71.11%, cirrhosis led to 71.11% of liver cancer, hepatitis B virus infection rate was 91.11%, HBsAg positive, anti-HBe positive and anti-HBc positive is the main infection pattern, accounting for 55.56%, primary liver cancer serum The levels of globulin (AFP) and α-L-fucosidase (AFU) were (511.8 ± 57.2) ng / ml and (39.9 ± 20.3) U / L, 0.05). Conclusion The middle-aged and elderly male patients are the high-risk patients with primary liver cancer. Hepatitis B and cirrhosis are the important causes of liver cancer. AFP and AFU are important clinical indicators. These characteristics have important clinical value in early diagnosis.