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目的探讨静息心率与原发性高血压发病危险因素聚集性的关系及临床意义。方法对298例符合原发性高血压的患者进行问卷调查,每位患者均测静息心率、血压、空腹血糖(FPG)、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDLc)、低密度脂蛋白胆固醇(LDLc)、纤维蛋白原(FG)及彩色多普勒超声心动图检查。根据检查结果将其分成4组:亚组1(有1项异常,n=106),亚组2(有2项异常,n=85),亚组3(有3项异常,n=69),亚组4(有3项以上异常,n=48)。另设102例正常血压组作为对照组。结果高血压各亚组间随着危险因素聚集性增多,静息心率逐渐增高。其中与对照组比较,亚组2、3和亚组4有显著差异(p<0.05,p<0.01和0.001),但与亚组1无差异(p>0.05)。等级相关分析显示:静息心率与高血压发病危险因素聚集程度呈正相关。结论静息心率与高血压动脉硬化的发展、靶器官损害及合并代谢异常有关。
Objective To investigate the relationship between resting heart rate and the clustering of risk factors of essential hypertension and its clinical significance. Methods A total of 298 patients with essential hypertension were surveyed. Each patient was measured for resting heart rate, blood pressure, fasting blood glucose (FPG), total cholesterol (TC), triglyceride (TG), high density lipoprotein Cholesterol (HDLc), low density lipoprotein cholesterol (LDLc), fibrinogen (FG) and color Doppler echocardiography. They were divided into four groups according to the test results: subgroup 1 (1 abnormality, n = 106), subgroup 2 (2 abnormalities, n = 85), subgroup 3 (3 abnormalities, n = 69) , Subgroup 4 (3 or more abnormalities, n = 48). Another 102 cases of normal blood pressure as a control group. Results As hypertension increased in all subgroups, the resting heart rate gradually increased. There was significant difference between subgroups 2, 3 and 4 (p <0.05, p <0.01 and 0.001), but no difference with subgroup 1 (p> 0.05). Hierarchical correlation analysis showed that resting heart rate was positively correlated with the degree of aggregation of risk factors of hypertension. Conclusion The resting heart rate is related to the development of arteriosclerosis, target organ damage and metabolic abnormalities in hypertensive patients.