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目的探讨重症少弱精子症与体外授精(IVF)妊娠结局之间的关系。方法回顾性分析来我院行IVF的29例重症少畸精子症患者,采用计算机辅助精液分析系统(CASA)分析精液常规参数。对IVF与各项精液参数进行Logistic回归分析。结果 A组(妊娠组)与C组(无可用胚胎未移植组)精子浓度及精子前向活动力/(a+b)%均具有统计学差异(P<0.05)。A组(妊娠组)与B组(未妊娠组)精子浓度以及精子前向活动力/(a+b)%均无统计学差异(P>0.05)。B组(未妊娠组)与C组(无可用胚胎未移植组)精子浓度以及精子前向活动力/(a+b)%均无统计学差异(P>0.05)。精液常规参数中精液量以及精子浓度对妊娠结局没有影响(P>0.05),仅精子前向活动率对妊娠结局有影响(P<0.05)。结论精子浓度以及精子前向活动力影响体外授精(IVF)妊娠结局,精子浓度以及精子前向活动力对预测IVF的妊娠结局有一定的临床意义。
Objective To investigate the relationship between severe oligoasthenospermia and IVF pregnancy outcome. Methods A retrospective analysis of 29 patients with severe oligozoospermia who had IVF in our hospital was performed. The routine parameters of semen were analyzed by computer assisted semen analysis system (CASA). Logistic regression analysis was performed on IVF and semen parameters. Results There was a significant difference in sperm concentration and (a + b)% sperm motility (P <0.05) between group A (pregnancy group) and group C (group without embryo transfer). There were no significant differences in sperm concentration and sperm motility / (a + b)% between group A (pregnancy group) and group B (nonpregnant group) (P> 0.05). There was no significant difference in sperm concentration and sperm motility before / (a + b)% between group B (nonpregnant group) and group C (without embryos not available) (P> 0.05). Semen volume and sperm concentration in routine parameters did not affect the pregnancy outcome (P> 0.05), but only the pre-sperm motility rate had an effect on pregnancy outcome (P <0.05). Conclusions Sperm concentration and forward sperm motility affect IVF pregnancy outcome, sperm concentration and sperm motility are of clinical significance in predicting IVF pregnancy outcome.