论文部分内容阅读
利用异体骨髓移植(BMT)治疗白血病或再障贫血日益增加.如果病人系白血病,为预防移植物排斥和根治恶性进展尚需预处理,这主要是投以大剂量细胞毒药物并常联用全身照射.预处理后即可利用组织相容的供体骨髓挽救骨髓衰竭的受体.异体骨髓移植主要的危险是感染、移植物抗宿主病(GVHD)、和不常见的移植排斥.这在移植后最初几周内危险最大.由于肺脏脆弱,所以肺部并发症是决定BMT成败的关键因素.典型者,极度中性粒细胞减少可出现于移植后的几天内,并持续3-4周.重笃感染,特别是肺部,几
The use of allogeneic bone marrow transplantation (BMT) for the treatment of leukemia or aplastic anemia is increasing.If the patient is leukemia, in order to prevent graft rejection and radical malignant progression need to be pre-treated, mainly cast high-dose cytotoxic drugs and often with the whole body Irradiation.Histologically compatible donor bone marrow can be used to rescue recipients of bone marrow failure after preconditioning.The main risks of allogeneic bone marrow transplantation are infection, graft-versus-host disease (GVHD), and uncommon graft rejection, The first few weeks after the most dangerous because of lung fragility, pulmonary complications are the key factors that determine the success or failure of BMT. Typically, extreme neutropenia can occur in a few days after transplantation and lasted 3-4 weeks Acute infection, especially the lungs, a few