论文部分内容阅读
手性对映体主导着自然的奇妙和生命的奥秘。生命组织中的手性环境能自然开启手性识别和激活手性,而人为介入的手性识别需要高灵敏度和高选择性相结合的分析手段。共振瑞利散射(RRS)光谱是一种高灵敏度且简便易行的分析方法,以有机染料、纳米粒子或量子点等作为光散射探针结合高灵敏度的RRS光谱,不仅能增强光散射,提高灵敏度,还能有效提高共振光散射光谱的选择性。而探索合成羟基氨基喹啉类衍生物手性光散射探针试剂与RRS相结合的手性识别则是一项创新工作。须确定羟基氨基喹啉类衍生物手性光散射探针试剂的作用机制以及分类筛选的应用研究,发展以手性光散射探针试剂为主导的识别手性对映体的RRS光谱分析,进一步拓展确立不经分离而同时测定手性对映体的新分析方法研究。
Chiral enantiomers dominate the wonders of nature and the mysteries of life. Chiral environment in living tissues can naturally open chiral recognition and activation chirality, while human interventional chiral recognition requires a combination of high sensitivity and high selectivity. Resonance Rayleigh scattering (RRS) spectroscopy is a highly sensitive and easy-to-use analytical method that incorporates high-sensitivity RRS spectroscopy with light-scattering probes such as organic dyes, nanoparticles or quantum dots to enhance light scattering and enhance Sensitivity, but also can effectively improve the resonance light scattering spectrum selectivity. The discovery of synthetic hydroxyquinoline derivatives of chiral light scattering probe reagent and RRS combined chiral recognition is an innovative work. The mechanism of the chiral light-scattering probe reagent of hydroxyquinoline derivatives and the applied research of classification and screening must be determined. RRS spectral analysis of the chiral enantiomer recognition by the chiral light-scattering probe reagent is further developed Develop a new analytical method for the simultaneous determination of chiral enantiomers without separation.