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目的：探讨非小细胞肺癌的Ⅰ型细胞间粘附分子（ＩＣＡＭ－１）的表达与侵袭和转移间的关系。方法：用免疫组化技术检测了５２例非小细胞肺癌及转移淋巴结中ＩＣＡＭ－１的表达。结果：２０例伴淋巴结转移的肺癌中，１４例ＩＣＡＭ－１表达阳性，相应淋巴结转移灶１３例阳性。３２例无淋巴结转移的肺癌中仅有６例阳性。结论：肺癌细胞ＩＣＡＭ－１的表达可作为判断癌细胞的侵袭及转移的指标。
Objective: To investigate the relationship between the expression of type I intercellular adhesion molecule (ICAM-1) and invasion and metastasis in non-small cell lung cancer. Methods: The expression of ICAM-1 in 52 NSCLC and metastatic lymph nodes was detected by immunohistochemistry. RESULTS: Of the 20 lung cancers with lymph node metastases, 14 were positive for ICAM-1 expression and 13 were positive for corresponding lymph node metastases. Only 6 of 32 lung cancers without lymph node metastases were positive. Conclusion: The expression of ICAM-1 in lung cancer cells can be used as an indicator to judge the invasion and metastasis of cancer cells.