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芳香族的溴化物在钯催化剂和六丁基二锡存在下经过均同偶联反应能生成二联芳烃。该合成方法在微波协助下只需15min便可得到60%~84%的得率,具有方便、快捷、普适等特点。各种缺电子和富电子芳烃和杂环溴化物,如苯、噻吩、呋喃、吡啶、噻唑和嘧啶的溴化物均易偶联。此方法还适应于稠环芳烃如萘、喹啉、苯并噻吩和吲哚的溴化物,且与羟基、氨基、羧基、醛基、酰基、酯基、硝基、氰基等反应性基团相容。反应是通过溴代芳烃与六丁基二锡先原位生成芳烃有机锡,芳烃有机锡再与溴代芳烃发生Stille偶联反应进行的。
Aromatic bromides can be generated by the same coupling reaction in the presence of palladium catalyst and hexabutyl tin. The synthesis method can obtain the yield of 60% -84% in just 15 minutes under the assistance of microwaves, and has the characteristics of convenience, quickness and universality. Various electron-deficient and electron-rich aromatics and heterocyclic bromides, such as benzene, thiophene, furan, pyridine, thiazole and pyrimidine, are easily coupled. This method is also applicable to the reaction of condensed aromatic hydrocarbons such as naphthalene, quinoline, benzothiophene and indole bromide with reactive groups such as hydroxyl group, amino group, carboxyl group, aldehyde group, acyl group, ester group, nitro group and cyano group Compatible. The reaction is carried out by generating Stille coupling reaction of aromatic hydrocarbon, organic tin and aryl bromide with aryl bromide and hexabutyl tin.