Notch是一组普遍存在于造血干／祖细胞、胚胎肝细胞、外周血淋巴细胞等多种细胞表面的跨膜蛋白。Notch在其配体的作用下可直接作为基因转录调节因子,对造血细胞的增殖、分化与抗凋亡能力起重要调节作用,研究证实Notch及其配体的正常表达是机体维持正常造血功能的重要条件,并在部分血液系统恶性疾病包括白血病及淋巴瘤的发生和发展中起重要作用。 Notch is a group of transmembrane proteins that are ubiquitous on many cell surfaces such as hematopoietic stem / progenitor cells, embryonic liver cells, and peripheral blood lymphocytes. Notch can play a direct role as a transcription factor in the proliferation, differentiation and anti-apoptotic ability of hematopoietic cells under the action of its ligands. Studies have shown that the normal expression of Notch and its ligand is the body’s normal hematopoietic function Important condition, and plays an important role in the occurrence and development of some hematological malignancies including leukemia and lymphoma.