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目的探讨丝氨酸/苏氨酸激酶PIM-1在前列腺癌组织中的表达及与血清PSA的关系。方法采用免疫组织化学法检测PIM-1在良性前列腺、高等级前列腺上皮内瘤和前列腺癌组织中的表达,分析PIM-1在前列腺癌中的表达水平与血清PSA水平的关系。结果PIM-1在前列腺癌中存在着明显的高表达,并且其表达水平与前列腺癌的恶性程度与分级呈正相关(P<0.01),与患者血清PSA水平无明显相关性(P>0.05)。结论PIM-1可作为一种新的诊断前列腺癌的肿瘤标志物。
Objective To investigate the expression of serine / threonine kinase PIM-1 in prostate cancer and its relationship with serum PSA. Methods Immunohistochemistry was used to detect the expression of PIM-1 in benign prostatic hyperplasia (BPH) and high-grade prostatic intraepithelial neoplasia (BPH) and prostate cancer. The relationship between the expression of PIM-1 in prostate cancer and serum PSA was analyzed. Results There was a significant positive correlation between the expression of PIM-1 and the grade of prostate cancer in prostate cancer (P <0.01). There was no significant correlation between the level of PIM-1 and the level of serum PSA (P> 0.05). Conclusion PIM-1 can be used as a new tumor marker for diagnosing prostate cancer.