儿童颅内肿瘤及其治疗所产生的认知功能损害,严重影响患儿身体健康和生活质量。其发生机制尚不清楚,可能与皮质和皮质下白质损伤有关,另与患儿性别和年龄、临床表现、肿瘤性质、部位和大小、治疗方式和治疗时间以及特定基因型等因素密切相关。通过现代影像技术和神经心理量表可对认知功能损害作出较为客观的评估。减少儿童颅内肿瘤认知功能损害的重点在于预防,治疗方案的改进也有助于减少损害,其目的在于获得最佳疗效的同时使治疗毒副作用降到最低。 Children’s intracranial tumors and their treatment of cognitive impairment, seriously affecting the children’s health and quality of life. Its mechanism is not clear, may be related to cortical and subcortical white matter damage, the other with the patient’s gender and age, clinical manifestations, tumor nature, location and size, treatment and treatment time and specific genotypes and other factors are closely related. Through the modern imaging technology and neuropsychological scale can make a more objective assessment of cognitive impairment. The key to reducing cognitive impairment in children with intracranial tumors is prevention, and improvements in treatment regimens also help to reduce the damage, with the aim of achieving the best possible efficacy while minimizing the therapeutic side effects.