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目的观察他汀类降脂对急性心肌梗死合并心房颤动患者的影响。方法急性心肌梗死合并心房颤动患者64例,随机分为常规药物治疗组27例和常规药物加阿托伐他汀对照组37例,治疗组阿托伐他汀10mg,每晚睡前顿服。患者门诊随访1次/月,随访6个月,观察两组患者血脂变化、阵发性房颤再发率和转为持续性(持续7d以上,但可转为窦性)或永久性房颤(持续性,不转为窦性)的发生率、缺血相关事件的发生率。结果治疗组血脂指标较治疗前明显改善,阵发性房颤再发率和转为持续性或永久性房颤的发生率、缺血相关事件的发生率明显低于对照组。结论降脂治疗能明显改善急性心肌梗死患者的临床预后,稳定斑块、改善血管内皮细跑功能及抗炎作用。
Objective To observe the effect of statin lipid lowering on patients with acute myocardial infarction complicated with atrial fibrillation. Methods Sixty-four patients with acute myocardial infarction and atrial fibrillation were randomly divided into two groups, 27 cases in the conventional drug treatment group and 37 cases in the conventional drug plus atorvastatin control group. Atorvastatin 10 mg in the treatment group was served overnight before bedtime. Patients were followed up 1 month / month, followed up for 6 months, observed changes in both groups of patients with blood lipids, paroxysmal atrial fibrillation recurrence and turned to persistent (for more than 7d, but can be converted to sinus) or permanent atrial fibrillation (Persistent, not converted to sinus), the incidence of ischemic-related events. Results The blood lipid of the treatment group was significantly improved than before treatment. The recurrence rate of paroxysmal atrial fibrillation and the incidence of persistent or permanent atrial fibrillation were significantly lower in the treatment group than in the control group. Conclusion Lipid-lowering therapy can significantly improve the clinical prognosis, stabilize the plaque, improve the function of capillary endothelial cells and anti-inflammatory in acute myocardial infarction patients.