目的探讨女性生殖道的血管肌纤维母细胞瘤(AMF)的临床病理表现、诊断及鉴别诊断。方法对2例AMF的病理特征及免疫组化表达进行分析,结合各类文献报道总结AMF的诊断及鉴别诊断。结果肿瘤边界清楚,瘤细胞呈梭形或圆梭形,由细胞密集区和稀疏区交替出现,血管丰富,瘤细胞多围绕血管生长。结论 AMF是一种主要发生于女性生殖器官的浅表部位的良性软组织肿瘤,主要与深部血管粘液瘤等鉴别。 Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of vascular myofibroblastic tumor (AMF) in female genital tract. Methods The pathological features and immunohistochemical expression of 2 cases of AMF were analyzed. The diagnosis and differential diagnosis of AMF were summarized in the literature. Results The tumor boundary was clear. The tumor cells were spindle-shaped or round-fusiform, alternating with densely populated and sparse regions. The blood vessels were abundant, and the tumor cells mostly grew around the blood vessels. Conclusions AMF is a benign soft tissue tumor that mainly occurs in superficial parts of female genital organs, and is mainly differentiated from deep vascular myxoma.