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百日咳是主要由百日咳杆菌引起的一种传染性强的急性呼吸系统疾病,主要见于发展中国家未接种相应疫苗的儿童。1978年我国实施计划免疫、普及儿童白百破疫苗接种以后,百日咳发病率明显下降,由使用疫苗前的100/10万～200/10万降低到20世纪90年代后的1/10万以下;近十年来,虽然百日咳发病率仍然保持在低水平,但一些地区出现反弹,局部地区还有暴发流行,发病率超过1/10万。该文就中国学者在百日咳的流行病学、实验室检测、治疗及疫苗等方面的研究历史及现状予以综述,强调卫生工作者对百日咳不能放松警惕,并应对其进行深入研究。
Pertussis is a highly contagious acute respiratory disease caused mainly by Bordetella pertussis, mainly found in children who have not been vaccinated in developing countries. In 1978, China’s implementation of planned immunization, popularization of children after Baitai broken vaccination, the incidence of pertussis decreased significantly from the pre-vaccine 100/100 ~ 200 / 100,000 to the 20th century after the 1990s less than 1/100 million; Although the incidence of pertussis has remained at a low level in the past decade, the rebound in some areas and the outbreak in some areas have hit the rate of more than 1/10 million. This article summarizes the history and present situation of Chinese scholars’ research on epidemiology, laboratory testing, treatment and vaccine of whooping cough, emphasizes that health workers can not relax their awareness of whooping cough and should study it in depth.