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Objective:The aim of this study was to compare the therapeutic effects of bladder preserving approach transurethral resection (TURBT) with additional intravesical instillation versus immediate cystectomy in patients with newly diagnosed stage T 1 G 3 bladder cancer. Methods:Clinical data of patients with newly diagnosed T 1 G 3 bladder cancer underwent immediate cystectomy (Group A) or TURBT with additional intravesical instillation (Group B) was collected from online databases. Meta-analysis that recommended by Cochrane Collaboration was done for the data obtained. Publication bias was examined using a funnel plot. Results:Four trails, including 434 patients, were eligible for this study. The general mortality rate of group A (74/149 = 49.7%) and group B (102/285 = 35.8%) was calculated and compared in RevMan 4.2, which showed the difference on general mortality rate between the two groups was not statistical significant, with the pooled RR = 1.23 (95% CI 1.10-1.70, P > 0.05). Conclusion:Compared with TURBT, immediate cystectomy may not reduce the general mortality rate to improve the forward survival rate.
Objective: The aim of this study was to compare the therapeutic effects of bladder preserving approach transurethral resection (TURBT) with additional intravesical instillation versus immediate cystectomy in patients with newly diagnosed stage T 1 G 3 bladder cancer. Methods: Clinical data of patients with newly Diagnosed T 1 G 3 bladder cancer underwent immediate cystectomy (Group A) or TURBT with additional intravesical instillation (Group B) was collected from online databases. Meta-analysis that recommended by Cochrane Collaboration was done for the data obtained. Publication bias was examined using The general mortality rate of group A (74/149 = 49.7%) and group B (102/285 = 35.8%) was calculated and compared in RevMan 4.2, which showed the difference on general mortality rate between the two groups was not statistically significant, with the pooled RR = 1.23 (95% CI 1.10-1.70, P> 0.05) Conclus ion: Compared with TURBT, immediate cystectomy may not reduce the general mortality rate to improve the forward survival rate.