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目的:探讨民族药铁棒锤不同炮制品中各元素的种类及含量。方法:利用电感耦合等离子体发射光谱法(ICP-AES)、原子吸收光谱法(AAS)和原子荧光光谱法(AFS)全面扫描并分析民族药铁棒锤生品及其8种不同炮制品中与人体健康和生命相关的常量元素、微量元素和重金属的种类及含量。结果:从铁棒锤中共检测出22种元素,与生品相比,不同炮制方法使某些元素发生了明显不同的变化,表明元素变化与炮制方法有较强的相关性。结论:3种光谱分析方法均能快速准确地分析药材中各种元素含量及其变化趋势,说明炮制和辅料不仅能改变元素含量而且能与有效成分一道发挥协同治疗疾病的效果,并发现藏医和羌医的炮制方法将导致重金属Hg的含量急剧增高,临床使用铁棒锤时存在安全隐患。实验拓宽了光谱法在中药安全性评价中的应用。
Objective: To explore the types and contents of the various elements in different products of the folk medicine iron hammer. Methods: A total of 8 samples of hammerhead products and their products were analyzed by inductively coupled plasma atomic emission spectrometry (ICP-AES), atomic absorption spectrometry (AAS) and atomic fluorescence spectrometry (AFS) Constituents and contents of major, minor and heavy metals related to human health and life. Results: Twenty-two kinds of elements were detected from the iron hammer. Compared with the raw product, different processing methods caused some obvious changes in some of the elements, indicating that there is a strong correlation between elemental changes and processing methods. Conclusion: All three kinds of spectroscopic methods can quickly and accurately analyze the content of various elements in medicinal materials and their changing trend, indicating that the processing and excipients not only can change the element content but also can work together with the effective ingredients to synergistically treat the disease. Qiang medicine processing methods will lead to a sharp increase in the content of heavy metals Hg, there is a safety risk in the clinical use of iron hammer. Experiments widen the application of spectroscopy in the safety evaluation of traditional Chinese medicine.