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目的探讨中西医联合治疗对脉络膜新生血管(CNV)性疾病的临床应用价值。方法将2011年3月至2015年6月收治的66例CNV性疾病患者按照治疗方法分为对照组(33例,33眼)与观察组(33例,34眼)。对照组仅采用动力疗法(PDT)治疗,观察组在此基础上联合中药健脾化浊方进行治疗。比较两组患者治疗前后ETDRS视力水平、治疗后FFA复查结果、治疗前后GLD值、治疗前后黄斑区视网膜厚度及治疗前后CNV复合体厚度。结果(1)两组患者治疗后ETDRS视力水平均显著高于治疗前(P均<0.05),治疗后两组ETDRS视力水平差异无统计学意义(P>0.05);(2)观察组患者治疗后眼底荧光素血管造影(FFA)复查结果显著优于对照组(P<0.05);(3)两组治疗后病灶最大线性距离(GLD)值均显著小于治疗前(P均<0.05),且观察组治疗后GLD值显著小于对照组治疗后(P<0.05);(4)两组患者治疗后黄斑区视网膜厚度均显著小于治疗前(P<0.05,P<0.01);(5)两组患者治疗后CNV复合体厚度均显著小于治疗前(P均<0.05),且观察组患者治疗后CNV复合体厚度显著小于对照组治疗后(P<0.05)。结论在PDT治疗的基础上采用中药健脾化浊方治疗CNV,可促使视网膜下层间水肿的吸收,缓解眼底渗出、水肿以及促进出血的吸收,使视网膜形态能够更好地恢复,疗效确切。
Objective To explore the clinical value of combination therapy of Chinese and Western medicine on choroidal neovascularization (CNV) diseases. Methods Sixty-six patients with CNV disease admitted from March 2011 to June 2015 were divided into control group (33 cases) and observation group (33 cases, 34 eyes) according to the method of treatment. The control group only treated with power therapy (PDT), the observation group on this basis combined with Chinese medicine spleen Huazhuo Fang for treatment. The visual acuity of ETDRS before and after treatment was compared between two groups. The results of FFA after treatment, the GLD before and after treatment, the thickness of retina before and after treatment and the thickness of CNV before and after treatment were compared. Results (1) The visual acuity of ETDRS was significantly higher in both groups after treatment than before treatment (P <0.05). There was no significant difference in ETDRS visual acuity between the two groups after treatment (P> 0.05). (2) The posterior fundus fluorescein angiography (FFA) was significantly better than the control group (P <0.05). (3) The maximum linear distance (GLD) of the two groups were significantly lower than before treatment (P <0.05) The GLD in observation group was significantly lower than that in control group after treatment (P <0.05). (4) The retinal thickness of macular area in both groups after treatment was significantly lower than that before treatment (P <0.05, P <0.01) After treatment, CNV complex thickness was significantly lower than before treatment (P <0.05), and the thickness of CNV complex in the observation group was significantly less than that of the control group after treatment (P <0.05). Conclusion The treatment of CNS on the basis of PDT treatment with traditional Chinese medicine Jianpi Huazhuo Fang can promote the absorption of subretinal edema, relieve fundus exudation, edema and promote the absorption of hemorrhage so that the retinal morphology can be restored better and the curative effect is better .